Employer: Computational & Systems Biology, Genome Institute of Singapore
Location: Singapore
Posted: Jun 26, 2013
Expires: Sep 24, 2013
- Description
-
We are looking for highly motivated researchers with a strong analytical and computational background and an interest in developing new algorithms for analyzing genome-scale RNA structure datasets.This work will be in collaboration with experts developing new high-throughput approaches to probe RNA structure genome-wide [1,2] and applying it to study the contribution of RNA structure to various cellular processes.
RNA structure is believed to be fundamental to its function and is important in almost every cellular process [1]. Alterations in RNA structure has also been implicated in several diseases. However the full contribution of RNA structure in biology is still not well understood. Recent developments in genome-wide structure probing methods have resulted in an explosion of RNA structure information [2]. These provide unprecedented detail in probing the structures of most RNAs in the cell and computational approaches to mine such data are still in their infancy. This is an exciting area and analysis of this new type of RNA structure data is likely to yield novel insights into the role of RNA structure and structural alterations in gene regulation, across diverse cellular states and diseases.
References[1] Wan, Y., Kertesz, M., Spitale, R. C., Segal, E. & Chang, H. Y. Understanding the transcriptome through RNA structure. Nat. Rev. Genet. 12, 641-655 (2011).
[2] Kertesz, M. et al. Genome-wide measurement of RNA secondary structure in yeast. Nature 467, 103-107 (2010).
Qualifications
———————— PhD in Computational Biology/Computer Science/Applied Mathematics/Genomics- Strong analytical and programming skills (C/C++, perl/python, UNIX environment). Candidates with significant experience in RNA structure prediction will be strongly preferred.
- To apply
- E-mail CV to nagarajann@gis.a-star.edu.sg
